Assistant Professor of Chemical Engineering and BioMedical Engineering, Carnegie Mellon University
Kris Noel Dahl
My research focuses on the discovery of sub-cellular biological phenomena associated with cancer, genetic diseases and stem cell differentiation. Since this work encompasses areas of science, engineering and medicine, I have incorporated aspects of comparative ethics and research ethics into my research and outreach. In addition, I regularly lecture on ethical issues to undergraduates, graduate students, MD-PhD students and others whose research transcends typical boundaries.
Our labs include facilities for the characterization for nanomaterials within cells. We examine cellular toxicology of nanomaterials, and encourage scientists and engineers across campus to perform biological characterization of their nanomaterials. To this end, I have organized symposia and lectured on ethical issues relating to nanomaterials, focusing in particular on the impact of these exciting new technologies on various aspects of human health as well as economical and societal impact.
Holt BD, Shawky JH, Dahl KN, Davidson LA, Islam MF (2015) Distribution of single-wall carbon nanotubes in the Xenopus laevis embryo after microinjection Journal of Applied Toxicology 36(4):568-78
Holt BD, Law J, Boyer PD, Wilson L, Dahl KN, Islam MF (2015) Sub-cellular partitioning and analysis of Gd3+-loaded ultra-short single-walled carbon nanotubes ACS Applied Materials & Interfaces 7(27):14593-602
Spagnol ST, Lin W, Booth EA, Ladoux B, Lazarus HM, Dahl KN (2015) Early passage dependence of mesenchymal stem cell mechanics influences cellular invasion and migration Annals of Biomedical Engineering 44(7):2123-31
Booth EA, Spagnol ST, Alcoser TA, Dahl KN (2015) Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force Soft Matter 11(32):6412-8
Shams H, Holt BD, Mahboobi SH, Jahed Z, Islam MF, Dahl KN, Mofrad MR (2014) Actin reorganization through dynamic interactions with single-wall carbon nanotubes. ACS Nano 8(1): 188-97
Ribeiro AJ, Khanna P, Sukumar A, Dong C, Dahl KN (2014) Nuclear stiffening inhibits migration of invasive melanoma cells. Cellular and Molecular Bioengineering 7(4):544-551
Kalinowski A, Yaron PN, Qin Z, Shenoy S, Buehler MJ, Lösche M, Dahl KN (2014) Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson-Gilford progeria syndrome Biophysical Chemistry 195:43-8
Booth-Gauthier EA, Du V, Ghibaudo M, Rape AD, Dahl KN, Ladoux B (2013) Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates Integrative Biology 5(3) 569-77
Boyer PD, Holt BD, Islam MF, Dahl KN (2012) Decoding membrane- versus receptor-mediated delivery of single-walled carbon nanotubes into macrophages using modifications of nanotube surface coatings and cell activity Soft Matter 9: 758-764
Holt BD, Shams H, Horst TA, Basu S, Rape AD, Wang Y-L, Rohde GK, Mofrad M, Islam MF, Dahl KN (2012) Altered cell mechanics from the inside: dispersed single wall carbon nanotubes integrate with and restructure actin Journal of Functional Biomaterials 3(20): 298-417